Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine (γ-L-glutamyl-L-cysteinyl-glycine) featuring an unusual gamma-peptide bond between the glutamate side chain and cysteine. As the most abundant low-molecular-weight thiol in mammalian cells, it serves as a central subject in redox biology research, participating in antioxidant defense, xenobiotic conjugation, and thiol-disulfide exchange chemistry.
In laboratory settings, glutathione is employed across a broad range of applications: as a substrate for glutathione peroxidases and glutathione S-transferases in enzymology assays, as a reducing agent in protein refolding protocols, in GSH/GSSG redox ratio determinations, and in cell culture studies examining oxidative stress responses and ferroptosis pathways where GSH depletion is a defining biochemical event.
Research has also examined glutathione’s role in mitochondrial function, cellular detoxification via mercapturic acid pathway conjugation, and the regulation of its biosynthesis through glutamate-cysteine ligase. Its well-characterized chemistry makes it a standard reference compound in thiol quantification and redox proteomics workflows.
This product is supplied as a lyophilized powder for laboratory research use only. It is not intended for human or veterinary use of any kind.
Research References
The following references are provided for informational purposes. This product is for laboratory research use only by qualified professionals.
