KPV (Lys-Pro-Val) is a synthetic tripeptide corresponding to the C-terminal fragment (residues 11-13) of alpha-melanocyte-stimulating hormone (α-MSH). Despite lacking the full melanocortin pharmacophore, this minimal sequence has been the subject of extensive investigation as a research tool for studying anti-inflammatory signaling pathways independent of classical melanocortin receptor-mediated cAMP induction.
In laboratory settings, KPV has been employed in cell culture models to examine modulation of NF-κB activation and downstream pro-inflammatory cytokine transcription in epithelial and immune cell lineages. Research has also explored its cellular uptake via the peptide transporter PepT1, a mechanism studied in intestinal epithelial cell models relevant to inflammation research.
Investigations using murine colitis models have examined KPV in the context of intestinal inflammation, with studies exploring nanoparticle-based and hydrogel delivery systems for targeted colonic release in experimental settings. These delivery-platform studies have made KPV a frequently used model peptide in oral peptide formulation research.
This product is supplied as a lyophilized powder for laboratory research use only. It is not intended for human or veterinary use of any kind.
Research References
The following references are provided for informational purposes. This product is for laboratory research use only by qualified professionals.
