GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a tripeptide-metal chelate with a long history of scientific investigation. First identified in the 1970s as a naturally occurring component of human plasma, the compound has since been studied across a range of disciplines. Its peptide backbone coordinates copper(II) ions through the histidine and glycine residues, yielding a stable complex that has demonstrated significant activity in gene expression research across diverse cell types.
Transcriptomic analyses — including microarray studies in human fibroblast cultures — have shown that GHK-Cu exposure is associated with differential expression of a substantial number of genes, with particular attention paid to those involved in ubiquitin-proteasome pathway activity, DNA repair, and antioxidant response. Additional published work has examined the compound’s influence on TGF-β signaling, integrin expression, and focal adhesion kinase activity in keratinocyte and endothelial cell models, reflecting its relevance to research at the interface of peptide biochemistry and cell biology.
Ares Research supplies GHK-Cu as a research-grade lyophilized powder with purity and identity documentation available. This product is intended exclusively for in vitro laboratory research. It is not approved for human administration, topical use, or any clinical application.
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All products are supplied solely as laboratory research reagents and are not for human consumption. Ares Research does not supply products to patients and makes no representations regarding therapeutic or medical use.
Ares Research operates as a chemical supplier only. It is not a compounding pharmacy and does not function as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.
